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07 Apr 2025 - 03:23 am

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07 Apr 2025 - 02:26 am

Exposure to phthalates during pregnancy can affect a newborn’s brain development, study finds
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Phthalates — the synthetic chemicals used in everyday products for food packaging, personal care, toys and more — have been linked to abnormal neurological development in infants.

Now, scientists may have discovered a biological pathway for how this phenomenon could occur. Researchers found that in utero exposure to phthalates is linked with altered metabolism of neurotransmitters and amino acids involved in brain maturation, according to a study published Wednesday in the journal Nature Communications.

The report is the first to use untargeted metabolomics — the study of all small molecules or metabolites in a biological system — to connect a mother’s phthalate exposure to a newborn’s metabolites, and those metabolites to neurological development, said senior study author Dr. Donghai Liang via email.
“This represents an important step forward in understanding how prenatal chemical exposures shape infant development at the molecular level,” added Liang, an associate professor of environmental health at Emory University’s Rollins School of Public Health in Atlanta.

First introduced in the 1920s, phthalates are used to make plastics softer and more flexible, primarily in polyvinyl chloride (PVC) products such as vinyl flooring, medical devices, children’s toys, food packaging or shower curtains. The chemicals also help lubricate substances and carry fragrances in various personal care products including deodorant; nail polish; perfumes; hair gels, sprays or shampoos; soaps; and body lotions.

Phthalates are also endocrine disruptors that have been linked to preterm birth, infant genital abnormalities, childhood obesity, asthma, cancer, cardiovascular issues, and low sperm count and testosterone in men.

“We conducted this study because phthalates are everywhere in our daily lives,” Liang said, hence their nickname “everywhere chemicals.”

Harming infant health
The findings are based on mother-newborn pairs enrolled in the Atlanta African American Maternal-Child Cohort between 2016 and 2018. In urine samples collected from 216 mothers between eight weeks and 14 weeks of gestation at visit one and 145 participants between 24 and 30 weeks’ gestation at visit two, the authors measured eight phthalate metabolites. Participants were around age 24 on average, and their levels of some phthalate metabolites were higher than the average determined by the National Health and Nutrition Examination Survey.

Within a day or two of birth, the authors collected the babies’ blood via a heel stick.

The team found prenatal phthalate levels were associated with lower levels of tyrosine, an amino acid and precursor to the thyroid hormone thyroxine. Thyroxine was also abnormally low in those with in utero phthalate exposure, and low thyroxine has been previously associated with greater vulnerability to illness and neurodevelopmental issues in newborns, the authors said. Tyrosine is also a precursor to the neurotransmitters dopamine, norepinephrine and epinephrine, all of which partly contribute to the body’s fight-or-flight response. Low levels of these neurotransmitters can lead to various problems, including anxiety, depression and trouble focusing.

Prenatal phthalate exposure was also linked with lower levels of the essential amino acid tryptophan, which converts into 5-hydroxytryptophan (or 5-HTP), which then turns into serotonin. Both 5-HTP and serotonin were also low. Serotonin has several critical roles in the body, including mood regulation, sleep, learning, memory, digestion and the body’s response to stress. Previous research has linked low serotonin with mood disorders such as depression and anxiety, sleep problems, and digestive issues.

Dannycit

07 Apr 2025 - 01:40 am

Ukrainian President Volodymyr Zelensky will meet US President Joe Biden and Vice President Kamala Harris in Washington on Thursday. Leon Neal/Getty Images
CNN
—
Ukrainian President Volodymyr Zelensky’s visit to the White House on Thursday could be his final chance to convince a receptive American president of his country’s war aims.
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The precise details of the “victory plan” Zelensky plans to present in separate meetings to President Joe Biden and Vice President Kamala Harris are unknown, having been closely held until they are presented to the American leaders.

But according to people briefed on its broad contours, the plan reflects the Ukrainian leader’s urgent appeals for more immediate help countering Russia’s invasion. Zelensky is also poised to push for long-term security guarantees that could withstand changes in American leadership ahead of what is widely expected to be a close presidential election between Harris and former President Donald Trump.

The plan, people familiar with it said, acts as Zelensky’s response to growing war weariness even among his staunchest of western allies. It will make the case that Ukraine can still win — and does not need to cede Russian-seized territory for the fighting to end — if enough assistance is rushed in.

That includes again asking permission to fire Western provided long-range weapons deeper into Russian territory, a line Biden once was loathe to cross but which he’s recently appeared more open to as he has come under growing pressure to relent.

Even if Biden decides to allow the long-range fires, it’s unclear whether the change in policy would be announced publicly.

Biden is usually apt to take his time making decisions about providing Ukraine new capabilities. But with November’s election potentially portending a major change in American approach to the war if Trump were to win, Ukrainian officials — and many American ones — believe there is little time to waste.
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Trump has claimed he will be able to “settle” the war upon taking office and has suggested he’ll end US support for Kyiv’s war effort.

“Those cities are gone, they’re gone, and we continue to give billions of dollars to a man who refused to make a deal, Zelensky. There was no deal that he could have made that wouldn’t have been better than the situation you have right now. You have a country that has been obliterated, not possible to be rebuilt,” Trump said during a campaign speech in Mint Hill, North Carolina, on Wednesday.

Comments like those have lent new weight to Thursday’s Oval Office talks, according to American and European officials, who have described an imperative to surge assistance to Ukraine while Biden is still in office.

As part of Zelensky’s visit, the US is expected to announce a major new security package, thought it will likely delay the shipping of the equipment due to inventory shortages, CNN previously reported according to two US officials. On Wednesday, the US announced a package of $375 million.

The president previewed Zelensky’s visit to the White House a day beforehand, declaring on the margins of the United Nations General Assembly his administration was “determined to ensure that Ukraine has what it needs to prevail in fight for survival.”
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“Tomorrow, I will announce a series of actions to accelerate support for Ukraine’s military – but we know Ukraine’s future victory is about more than what happens on the battlefield, it’s also about what Ukrainians do make the most of a free and independent future, which so many have sacrificed so much for,” he said.

Donaldflani

07 Apr 2025 - 01:39 am

Ukrainian President Volodymyr Zelensky will meet US President Joe Biden and Vice President Kamala Harris in Washington on Thursday. Leon Neal/Getty Images
CNN
—
Ukrainian President Volodymyr Zelensky’s visit to the White House on Thursday could be his final chance to convince a receptive American president of his country’s war aims.
megaweb14.at
The precise details of the “victory plan” Zelensky plans to present in separate meetings to President Joe Biden and Vice President Kamala Harris are unknown, having been closely held until they are presented to the American leaders.

But according to people briefed on its broad contours, the plan reflects the Ukrainian leader’s urgent appeals for more immediate help countering Russia’s invasion. Zelensky is also poised to push for long-term security guarantees that could withstand changes in American leadership ahead of what is widely expected to be a close presidential election between Harris and former President Donald Trump.

The plan, people familiar with it said, acts as Zelensky’s response to growing war weariness even among his staunchest of western allies. It will make the case that Ukraine can still win — and does not need to cede Russian-seized territory for the fighting to end — if enough assistance is rushed in.

That includes again asking permission to fire Western provided long-range weapons deeper into Russian territory, a line Biden once was loathe to cross but which he’s recently appeared more open to as he has come under growing pressure to relent.

Even if Biden decides to allow the long-range fires, it’s unclear whether the change in policy would be announced publicly.

Biden is usually apt to take his time making decisions about providing Ukraine new capabilities. But with November’s election potentially portending a major change in American approach to the war if Trump were to win, Ukrainian officials — and many American ones — believe there is little time to waste.
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Trump has claimed he will be able to “settle” the war upon taking office and has suggested he’ll end US support for Kyiv’s war effort.

“Those cities are gone, they’re gone, and we continue to give billions of dollars to a man who refused to make a deal, Zelensky. There was no deal that he could have made that wouldn’t have been better than the situation you have right now. You have a country that has been obliterated, not possible to be rebuilt,” Trump said during a campaign speech in Mint Hill, North Carolina, on Wednesday.

Comments like those have lent new weight to Thursday’s Oval Office talks, according to American and European officials, who have described an imperative to surge assistance to Ukraine while Biden is still in office.

As part of Zelensky’s visit, the US is expected to announce a major new security package, thought it will likely delay the shipping of the equipment due to inventory shortages, CNN previously reported according to two US officials. On Wednesday, the US announced a package of $375 million.

The president previewed Zelensky’s visit to the White House a day beforehand, declaring on the margins of the United Nations General Assembly his administration was “determined to ensure that Ukraine has what it needs to prevail in fight for survival.”
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“Tomorrow, I will announce a series of actions to accelerate support for Ukraine’s military – but we know Ukraine’s future victory is about more than what happens on the battlefield, it’s also about what Ukrainians do make the most of a free and independent future, which so many have sacrificed so much for,” he said.

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07 Apr 2025 - 01:29 am

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07 Apr 2025 - 12:32 am

Guatemala has pledged a 40% increase in deportation flights carrying Guatemalans and migrants of other nationalities from the United States, President Bernardo Arevalo announced Wednesday during a press conference with US Secretary of State Marco Rubio.
kra32.cc
Guatemala has also agreed to create a task force for border control and protection along the country’s eastern borders. The force, composed of members of the National Police and army, will be tasked with fighting “all forms of transnational crime,” Arevalo said.
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Foreign nationals who arrive in Guatemala through deportation flights will be repatriated to their home countries, Arevalo said, adding that the US and Guatemala would continue to have talks on how the process would work and how the US would cooperate.
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Arevalo also said that Rubio has voiced his support for developing infrastructure projects in the Central American nation. He added that his government would send a delegation to Washington in the coming weeks to negotiate deals for economic investments in Guatemala – which he said would incentivize Guatemalans to stay in their home country and not migrate to the US.

Arevalo said Guatemala has not had any discussions about receiving criminals from the US as El Salvador’s president has offered. He also insisted his country has not reached a “safe third country” agreement with the United States, which would require migrants who pass through Guatemala to apply for asylum there rather than continuing to the US.
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